Making Sure PaLRaP Remains Healthy and Strong

Making sure late endosomes are on time

Early endosomes collect and sort cargoes before maturing into late endosomes that ferry those cargoes to the lysosome. Liu et al. identify two proteins that spur early endosomes to transform and thus help ensure that cellular deliveries occur on schedule (1). As an early endosome morphs into a late endosome, it revamps its molecular composition. Early endosomes carry the GTPase Rab5, which attr...

Not a Sure Thing: Making Regulatory Choices

Myosin remains strong as muscle contracts

Myosin remains strong as muscle contracts A muscle held at fi xed length under a heavy load will contract rapidly if that load is suddenly decreased, reducing the force the muscle exerts as its velocity increases. During this contraction, what happens within the muscle fi ber? According to the prevailing model, all the myosin motors remain attached to actin fi laments, and the elasticity of ind...

Commentary: Sure I'm Sure: Prefrontal Oscillations Support Metacognitive Monitoring of Decision Making

Fragile-to-strong crossover in supercooled liquids remains elusive.

Transport properties of glass forming liquids change markedly around an onset temperature To. For temperatures T above To, these properties depend little with T , while for T < To these properties are super -Arrhenius – varying faster than exponentially in 1/T . Upon lowering temperature significantly further, theory [1] predicts that reversible transport in a supercooled liquid, if it can be o...